Biological drugs activate the complement system

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We have investigated to which extent biopharmaceutics activate the complement system. This is important, since the complement system is designed to mark unwanted components like viruses in our blood, for degradation. If a drug activates the complement system, it will be eliminated faster, but it can also trigger other immune-related events. This work was in collaboration with Profs. Silje Skrede at Dept. Clin. Sci, Tom Eirik Mollnes at Nordland Hospital, and Kjell-Morten Myhr and Øyvind Thorkildsen at Neuro-SysMed, University of Bergen. The work was recently published in International Immunopharmacology.

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