Monthly Archives: January 2018

Article with Maite and Aurora on enzyme-loaded nanoparticles

Just after Christmas, we got the nice news that our manuscript on tyrosine hydroxylase (TH) in nanoparticles was accepted for publication in Bioconjugate Chemistry. This work describes an amitious, but very elegant principle for treatment of neurodegenerative diseases like Parkinson’s disease. In this disease, the patients suffer from loss of enzyme activity. We showed that it was possible to load functional enzymes into nanoparticles. The nanoparticles internalize the functional enzymes both in cells in culture, and in animals. The work was mainly done by Maite and Fredrik in Aurora Martinez’ group, but also with contributions from Edvin and myself.