Monthly Archives: December 2021

New formulation for repurposing of drugs

Repurposing, or redefinition of drugs from one disease to another, is a way to improve treatment of diseases with few therapy options. For acute myeloid leukaemia, the anti-psychotic drug chlorpromazine has showed good effect in cell cultures in vitro. However, it has quite dramatic effects on the central nervous system in non-psychotic individuals. PhD student Edvin Tang Gundersen has developed a nanoparticle which encapsulates chlorpromazine, and prevents it from entering the central nervous system. The formulation is efficient towards AML cells and the nanoparticles prevent the encapsulated molecules crossing from the blood into the central nervous system in zebrafish larvae. The work was recently published in International Journal of Pharmaceutics.